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Synfacts 2009(6): 0627-0627
DOI: 10.1055/s-0029-1216714
DOI: 10.1055/s-0029-1216714
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Rhodium Disulfoxide Catalyzed 1,4-Addition to Cyclic Olefins
J. J. Bürgi, R. Mariz, M. Gatti, E. Drinkel, X. Luan, S. Blumentritt, A. Linden, R. Dorta*
Universität Zürich, Switzerland
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
25. Mai 2009 (online)
Significance
New disulfoxide ligands are synthesized and successfully applied to the rhodium-catalyzed asymmetric 1,4-addition of aryl boronic acids to cyclic unsaturated ketones or lactones. Very high chemical yields and enantioselectivities are obtained with less than 1 mol% catalyst loading in this reaction. Mechanistic insights of this new ligand and the origin of enantioselectivity are also discussed.