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Synfacts 2009(6): 0665-0665
DOI: 10.1055/s-0029-1216683
DOI: 10.1055/s-0029-1216683
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Iron-Catalyzed Oxidative Aryl-Alkyl Cross-Coupling of Organozinc Reagents
G. Cahiez*, L. Foulgoc, A. Moyeux
Université de Paris 13, Bobigny, France
Further Information
Publication History
Publication Date:
25 May 2009 (online)
![](https://www.thieme-connect.de/media/synfacts/200906/lookinside/thumbnails/10.1055-s-0029-1216683-1.jpg)
Significance
This reaction is the first example of aryl-alkyl oxidative cross-coupling. Functionalized aryl and alkyl zinc compounds can be used successfully. The reaction proceeds in the presence of an environmentally benign iron catalyst. This method opens a way to new types of cross-couplings, complementary to the classical variant.