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Synfacts 2009(6): 0592-0592
DOI: 10.1055/s-0029-1216672
DOI: 10.1055/s-0029-1216672
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of BYK 405879
A. M. Palmer*, M. Webel*, C. Scheufler, D. Haag, B. Müller
NYCOMED GmbH, Konstanz and Singen, Germany
Further Information
Publication History
Publication Date:
25 May 2009 (online)
Significance
The target molecule is a reversible inhibitor of the gastric proton pump enzyme and is being developed for the treatment of gastroesophageal reflux disease. The key step, a Noyori asymmetric transfer hydrogenation, required development of a special catalyst L.