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DOI: 10.1055/s-0029-1214375
Similarities and Differences in the Pathogenesis of Alcoholic and Nonalcoholic Steatohepatitis
Publication History
Publication Date:
22 April 2009 (online)
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ABSTRACT
Subpopulations of individuals with alcohol-induced fatty livers and nonalcoholic steatosis develop steatohepatitis. Steatohepatitis is defined histologically: increased numbers of injured and dying hepatocytes distinguish this condition from simple steatosis. The increased hepatocyte death is generally accompanied by hepatic accumulation of inflammatory cells and sometimes increases in myofibroblastic cells, leading to hepatic fibrosis and eventually, cirrhosis. The purpose of this review is to summarize similarities and differences in the pathogenesis of steatohepatitis in alcoholic fatty liver disease and nonalcoholic fatty liver disease.
KEYWORDS
Alcoholic fatty liver disease - nonalcoholic fatty liver disease - pathogenesis - steatohepatitis
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Anna Mae DiehlM.D.
Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Genome Sciences Research Building-1
595 LaSalle Street, Suite 1073, DUMC 3256, Durham, NC 27710
Email: annamae.diehl@duke.edu