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Exp Clin Endocrinol Diabetes 1996; 104(2): 102-105
DOI: 10.1055/s-0029-1211430
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Observations on the decay of glycated hemoglobin HbA1c in diabetic patients

M. E. Rech
  • Diabetes Outpatient Clinic, Department of Metabolic Diseases and Nutrition, Heinrich-Heine-University of Düsseldorf/Germany
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Publication History

Publication Date:
15 July 2009 (online)

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Summary

In 44 diabetic patients, who within 7 days lowered their average glycemia by 140 to 220 mg% and kept it at this level over a mean of 36 days, HbAlc was measured repeatedly by HPLC (normal range 4.2–5.6% of total hemoglobin). Thereby, the maximum decay rate of HbAlc could be observed in vivo as being 0.1% per day which is consistent with previous theoretical considerations by other authors. Some clinical implications that this finding may have for diabetic patients are being discussed.

Key words

Diabetes mellitus - diabetic retinopathy - pregnancy - metabolic control