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Exp Clin Endocrinol Diabetes 1992; 99(3): 159-163
DOI: 10.1055/s-0029-1211160
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

In Vitro Effect of Vanadate on Content, Secretion and Biosynthesis of Insulin in Isolated Islets of Normal Wistar Rats

Christel Voss, Irene Herrmann, K. Hartmann, H. Zühlke
  • Institute of Biochemistry, Medical School, Ernst-Moritz-Arndt-University, Greifswald/Germany
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Publication History

1991

Publication Date:
16 July 2009 (online)

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Summary

In in vitro experiments the effect of (Na-ortho)vana-date (1—50 µmol/1) on content, secretion and biosynthesis of insulin was investigated in isolated islets of normal Wistar rats. Compared with controls insulin content is unchanged, but insulin secretion and biosynthesis rate are significantly reduced; secretion is significantly more reduced in the basal than in the stimulating glucose medium.

Our results support the view that vanadate exhibits its influence on insulin metabolism in the beta cell already.

Key words

Vanadate - Beta cell - Insulin - Rat