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Exp Clin Endocrinol Diabetes 1992; 99(3): 143-146
DOI: 10.1055/s-0029-1211156
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Time-Related Effects of Thyrotropin-Releasing Hormone (TRH) on the Pituitary-Thyroid Axis and Extrathyroidal Targets

M. Nink, P. Weber, U. Krause, J. Beyer
  • IIIrd Medical Clinic-Endocrinology (Head: Univ.-Prof. Dr. J. Beyer), Mainz University Hospital, Mainz/Germany
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Publication History

1992

Publication Date:
16 July 2009 (online)

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Summary

Thyrotropin-releasing hormone (TRH) is a tripeptide and acts as a stimulator of the pituitary-thyroid axis as well as having a great number of well defined extrathyroidal functions. Studies in experimental animals have shown, that TRH also has a role as a neuromodulator within the autonomous nervous system.

In this study we analyzed the effects following peripheral administration of TRH (200 µg, 400 µg) in patients with endocrinological disorders and in healthy females and males. By means of a questionnaire, patients were asked about possible (side-) effects; ventilatory and cardiovascular monitoring was performed during steady state. The pulsatile TSH-secretion pattern was analyzed and thyroid and stress hormones were measured in the blood prior to and following TRH i.v.

Frequent symptoms afer TRH were feeling of heat (58%), stimulation of respiration (61%), palpitations (39%), micturition urge (52 %) and restlessness (32 %). Apparative monitoring demonstrated a short stimulation of respiration and an increase of heart rate. After 400 µg TRH i.V., blood levels of ACTH decreased slightly (p < 0.01) but levels of T3, T4, epinephrine, norepinephrine and cortisol remained unchanged (p > 0.05). TSH-levels were low during daytime and showed a surge at night.

Key words

Cardiovascular system - Hormones - Thyrotropin-releasing hormone - Respiration