Download PDF
Exp Clin Endocrinol Diabetes 1990; 96(6): 331-334
DOI: 10.1055/s-0029-1211030
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Influence of Microinjection of Insulin into the Ventromedial Hypothalamus on Acetate Metabolism in Rumen Epithelium of Sheep

H. Saito, H. Kaba, A. Ohri, T. Sato, K. Seto, F. Kimura1 , M. Kawakami1 , A. L. Black2
  • First Department of Physiology (Chairman: Prof. Dr. K. Seto), Kochi Medical School, Nankoku
  • 1Second Department of Physiology, (Chairman: Prof. Dr. F. Kimura), Yokohama City University School of Medicine, Yokohama/Japan
  • 2Department of Physiological Sciences, (Chairman: Prof. Dr. A. L. Black) University of California/Davis/USA
Further Information

Publication History

1990

Publication Date:
16 July 2009 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

Injections of 50 μU insulin into the ventromedial hypothalamic nuclei (VMH) in intact sheep decreased the rates of 14C transfer from 14C-1-acetate into CO2, glucose, ketone bodies, and increased the rates into triglyceride and phospholipids in rumen epithelium of sheep. Insulin injections into the parietal cortex of intact sheep or into the VMH of sheep with VMH lesions had no effect on the acetate metabolism in rumen epithelium as compared with the control groups which received saline injections into the same brain regions. These results support the view that the VMH serves as an integral part of an insulin-sensitive brain regulatory system in the acetate metabolism of rumen epithelium.

Key words

Insulin - Acetate metabolism - Ventromedial hypothalamus - Rumen epitheium