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Exp Clin Endocrinol Diabetes 1990; 96(6): 328-330
DOI: 10.1055/s-0029-1211029
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Hypothalamic 5-Hydroxytryptamine Metabolism Is not Influenced by Streptozotocin-Diabetes Induced at Neonatal Age

R. Huupponen, M. Koulu, Ullamari Pesonen
  • Department of Pharmacology (Head: Prof. P. Neuvonen), University of Turku, Turku/Finland
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Publication History

1989

Publication Date:
16 July 2009 (online)

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Summary

Rats were rendered diabetic at neonatal age by an intraperitoneal injection of streptozotocin (90 mg/kg). At 8—10 weeks of age, their 5-HT and 5-HIAA levels in different hypothalamic nuclei (ventromedial, paraventricular, periventricular, supraoptical and suprachiasmatic nuclei) were similar to control animals which received vehicle only. It is concluded that the combination of mild hyperglycemia and hypoinsulinemia does not affect hypothalamic 5-HT metabolism in rats.

Key words

STZ-diabetes - Hypothalamic 5-HT - Animal models