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Exp Clin Endocrinol Diabetes 1990; 96(5): 138-142
DOI: 10.1055/s-0029-1211002
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Aldosterone Content in Plasma, Erythrocytes and Skeletal Muscles in Icenko-Cushing's Syndrome

H. M. Yakovlev, V. A. Yakovlev, V. M. Trofimov, S. B. Shustov, A. G. Vavilov
  • S. M. Kirov Medico-Military Academy (Head: Prof. H. M. Yakovlev) Leningrad/USSR
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Publication History

1989

Publication Date:
16 July 2009 (online)

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Summary

Aldosterone concentration was measured in plasma, erythrocytes and skeletal muscles in 34 patients with Icenko-Cushing's syndrome (ICS). It was established that aldosterone levels in the erythrocytes and whole blood of these patients were elevated, while aldosterone content in the plasma and muscular tissue of the patients was normal. Only in a small group of patients (N = 4) aldosterone levels positively correlated with arterial pressure (BP) and central hemodynamic parameters. Following 10 minutes of headdown tilt (−15°), erythrocyte aldosterone level in the group of healthy controls (N = 12) was markedly elevated, but not in the group of patients with ICS. The results of the study suggest that erythrocytes can be viewed as a mobile aldosterone “depot” and may operate to mediate depressor effects of certain hormones on central hemodynamics.

Key words

Icenko-Cushing's syndrome - Aldosteron - Erythrocyte - Skeletal muscles - Arterial pressure