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Exp Clin Endocrinol Diabetes 1990; 96(4): 1-7
DOI: 10.1055/s-0029-1210981
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Suppression of Antral Formation in the Ovarian Follicles of Marmosets by Human Ovarian Follicular Fluid Protein

T. D. Nandedkar, J. K. Shahid, S. B. Moodbidri
  • Department of Biology (Head: Dr. T. D. Nandedkar) Institute for Research in Reproduction (Head: Dr. T. C. Anand Kumar) Parel, Bombay/India
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Publication History

1989

Publication Date:
16 July 2009 (online)

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Summary

Ovarian follicular fluid peptide (OFFP) has earlier been shown to inhibit maturation of large follicles and ovulation in mice. An active fraction hGF2, obtained following partial purification from human ovarian follicular fluid, was injected at a dose of 20 μg to 4-month-old immature marmosets, every alternate day for 2 months. The animals were autopsied at 4 and 6 months of age. Ovarian morphology indicated the appearance of large follicles at 6 months of age in the control group. In contrast, in hGF2 treated marmosets development up to preantral follicles could be seen at 6 months. Furthermore, only in 1 out of the 5 treated marmosets, presence of large preantral follicles was observed and in the remaining 4 animals only primary and secondary follicles were noted. These results reveal that OFFP suppresses follicular development and antrum formation in marmosets.

Key words

Ovarian follicular fluid - Antral follicles - Marmoset