Download PDF
Exp Clin Endocrinol Diabetes 1990; 95(3): 385-388
DOI: 10.1055/s-0029-1210980
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Ambulatory Activity and Dopamine Turnover in Streptozotocin-Induced Diabetic Rats

Y. Shimomura, H. Shimizu, M. Takahashi, Y. Uehara, I. Kobayashi, S. Kobayashi
  • Division, of Endocrinology, Department of Medicine, First Department of Internal Medicine, Gunma University School of Medicine, Maebashi/Japan
Further Information

Publication History

1989

Publication Date:
16 July 2009 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

This study was undertaken to investigate the changes of ambulatory activity and dopamine turnover (DOPAC/DA ratio) in streptozotocin (STZ 60 mg/kg ip)-induced diabetic rats employing the Gunma University-type special apparatus. A significant decrease in ambulatory activity was observed during the dark phase but not during the light phase 1 month after administration of STZ. Moreover, through the precise observation during light phase, we have found out that a significant decrease compared to control periods was observed during 9:00 to 12:00, whereas increase during 12:00 to 15:00 and 5:00 to 18:00 in the diabetic rats. In addition, a significant decrease in dopamine turnover compared to control rats was seen during dark phase (20:00), when significantly decreased ambulation was observed in the diabetic rats compared to control rats. However, no difference in dopamine turnover was observed during light phase (8:00), when ambulation was not significantly different from both groups.

These results may suggest that fluctuation in dopamine turnover may be closely related to the ambulatory activity in STZ-induced diabetic rats.

Key words

Ambulation - Dopamine turnover - STZ-induced diabetic rats