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Exp Clin Endocrinol Diabetes 1990; 95(3): 345-352
DOI: 10.1055/s-0029-1210975
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Circulating Levels of Placental Protein 10 (PP 10) in Diabetic Pregnancy Complicated by Retinopathy

V. Briese1 , D. G. Szabo2 , E. Glöckner1 , R.-R. Strache3 , P. Heinke1 , H. Hopp1 , H.-H. Buettner3
  • 1Central Institute of Diabetes “Gerhardt Katsch ” (Director : OMR Prof. Dr. sc. med. H. Bibergeil), Department of Obstetrics and Gynecology (Director : Dr. sc. med. H. Hopp), Karlsburg/GDR
  • 2Institute of Biochemistry, University Medical School (Director : Prof. Dr. sc. med. H. Alkonyi), Pecs/Hungary
  • 3Clinic of Obstetrics and Gynecology (Director : Prof. Dr. sc. med. H.-H. Buettner), Wismar/GDR
Further Information

Publication History

1989

Publication Date:
16 July 2009 (online)

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Summary

Placental protein 10 (PP 10) is a soluble tissue antigen of the placenta. PP 10, a glycoprotein, was tested in diabetic pregnancy complicated by retinopathy. A continuous increase in PP 10 serum levels until weeks 35—36 is followed by a fall thereafter up to term. The mean of the healthy control group between 32 and 39 weeks gestation was 22 ± 10 μg/l. In diabetic pregnancies complicated by retinopathy there were measured 69 ± 24 μg/l in benign form and 77 ± 26 μg/l in proliferative form. Both of these values are significantly (p < 0.05) above the control values. Increased PP 10 levels in diabetic pregnancy complicated by retinopathy are probably caused by placental and amniotic leakages.

Key words

Placental protein 10 (PP 10) - PP 10 serum levels in high risk pregnancies - PP 10 in diabetic retinopathy