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Exp Clin Endocrinol Diabetes 1990; 95(3): 301-305
DOI: 10.1055/s-0029-1210969
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Bifemelane Hydrochloride Reduces Plasma β-Endorphin-Like Immunoreactivity Levels in Rats

T. Mitsuma1 , Y. Hirooka1 , K. Yuasa1 , T. Nogimori2
  • 1Fourth Department of Internal Medicine, Aichi Medical University, Nagakute, Aichi/ Japan
  • 2Department of Internal Medicine, Konanshowa Hospital, Konan, Aichi/ Japan
Further Information

Publication History

1989

Publication Date:
16 July 2009 (online)

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Summary

The effect of bifemelane hydrochloride on plasma β-endorphin-like immunoreactivity (β-En-LI) levels in rats was studied. Bifemelane hydrochloride (25 mg/kg) was injected i.p., and the animals were decapitated at various times after the administration. The plasma β-En-LI levels were measured by radioimmunoassay. The effect of bifemelane hydrochloride on β-En-LI release from the anterior pituitary was also investigated by means of an in vitro experiment. The β-En-LI content in the hypothalamus and pituitary gland did not change significantly after bifemelane hydrochloride injection. The plasma β-En-LI levels decreased significantly in a dose-related manner with a nadir at 40 min after the injection. The β-En-LI release in vitro from the anterior pituitary was inhibited with the addition of bifemelane hydrochloride.

The findings suggest that bifemelane hydrochloride acts on the anterior pituitary to inhibit β-En-LI release.

Key words

Bifemelane hydrochloride - β-Endorphin - Anterior pituitary - Rat