Download PDF
Exp Clin Endocrinol Diabetes 1990; 95(3): 287-291
DOI: 10.1055/s-0029-1210967
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

(6R)-5,6,7,8-tetrahydr-α-biopterin Affects Vasopressin and Oxytocin Release from Rat Neurointermediate Lobe In Vitro*

Joanna Ciosek, Jan W. Guzek
  • Department of Pathophysiology (Head: Prof. Dr. med. J. W. Guzek), University School of Medicine, Łódź, Poland
* Conducted under contract No MZ X/21-II/013 with the Polish Ministry of Health and Social Welfare.
Further Information

Publication History

1989

Publication Date:
16 July 2009 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

Incubation of neurointermediate lobes in Locke's solution containing 0.13 μmol · l−1 (6R)-5,6,7,8-tetrahydro-alpha-biopterin dihydrochloride (THB4) resulted in an inhibition of bioassayed vasopressin secretion and in an increase of that of oxytocin both under resting conditions as well as during depolarization due to excess potassium.

It is suggested that some events related to THB4 and localized in the neural lobe are involved in the mechanism of vasopressin and oxytocin release.

Key words

Biopterines - Vasopressin - Oxytocin - Neurohypophysis