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Exp Clin Endocrinol Diabetes 1990; 95(2): 259-261
DOI: 10.1055/s-0029-1210961
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Influence of Electrical Stimulation of the Hypothalamus on Ovarian Steroidogenesis in Hypophysectomized and Adrenalectomized Rats

H. Saito, H. Kaba, T. Sato, M. Kondo, Y. Takeshima, N. Edashige1 , K. Seto, M. Kawakami2
  • First Department of Physiology (Chairman: Prof. Dr. K. Seto), Kochi Medical School, Nankoku
  • 1Department of Medical Technology (Chairman: Prof. Dr. S. Sato), Kochi Gakuen College, Kochi
  • 2Second Department Physiology (Former Chairman: Prof. Dr. M. Kawakami), Yokohama City University School of Medicine, Yokohama/Japan
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Publikationsverlauf

1989

Publikationsdatum:
16. Juli 2009 (online)

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Summary

The effects of electrical stimulation of the lateral hypothalamic area (LHA), periventricular arcuate nucleus (ARC) and ventromedial hypothalamic nucleus (VMH) on the rates of 14C transfer from 14C-1 acetate into ovarian steroids in ovarian slices of hypophysectomized and adrenalectomized (H-A) rats were investigated. The 14C transfer rates into estrogen and 20αc-hydroxy-pregn-4-en-3-one (20α-OH-P) were decreased by LHA stimulation. The stimulation of the ARC and VMH increased the rates of 14C transfer into estrogen, progesterone and 20αc-OH-P. Erom these results, it might be suggested that these hypothalamic structures were involved in the regulation of ovarian steroidogenesis without participation of the pituitary and adrenal.

Key words

Hypothalamus - Ovarian Steroids - Hypophysectomized rats