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DOI: 10.1055/s-0029-1210961
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Influence of Electrical Stimulation of the Hypothalamus on Ovarian Steroidogenesis in Hypophysectomized and Adrenalectomized Rats
Publikationsverlauf
1989
Publikationsdatum:
16. Juli 2009 (online)
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Summary
The effects of electrical stimulation of the lateral hypothalamic area (LHA), periventricular arcuate nucleus (ARC) and ventromedial hypothalamic nucleus (VMH) on the rates of 14C transfer from 14C-1 acetate into ovarian steroids in ovarian slices of hypophysectomized and adrenalectomized (H-A) rats were investigated. The 14C transfer rates into estrogen and 20αc-hydroxy-pregn-4-en-3-one (20α-OH-P) were decreased by LHA stimulation. The stimulation of the ARC and VMH increased the rates of 14C transfer into estrogen, progesterone and 20αc-OH-P. Erom these results, it might be suggested that these hypothalamic structures were involved in the regulation of ovarian steroidogenesis without participation of the pituitary and adrenal.
Key words
Hypothalamus - Ovarian Steroids - Hypophysectomized rats