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Exp Clin Endocrinol Diabetes 1990; 95(1): 91-96
DOI: 10.1055/s-0029-1210939
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The Higher Frequency of Type I (insulin-dependent) Diabetes in Fathers than in Mothers of Type I-Diabetic Children*)

Ilona Rjasanowski, P. Heinke, D. Michaelis, T. L. Kurajewa1
  • Central Institute of Diabetes “Gerhardt Katseh”, Karlsburg/GDR (Director: OMR Prof. Dr. sc. med. H. Bibergeil)
  • 1Institute of Experimental Endocrinology and Chemistry of Hormones, Academy of Sciences, USSR/Moscow
*) Dedicated to OMR Prof. Dr. H. Bibergeil on the occasion of his 65th birthday.
Further Information

Publication History

1989

Publication Date:
16 July 2009 (online)

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Summary

In 868 insulin-treated diabetic children and adolescents with onset of IDDM under age 20 we investigated the frequency of IDDM and NIDDM in all first-degree relatives. On the basis of the National Diabetes Register of the GDR the age-corrected lifetime risk for the development of IDDM and NIDDM was calculated for the general population and for parents and siblings of diabetic children. The age-corrected risk for IDDM, but not for NIDDM, is statistically significantly higher in fathers (10.26 ± 1.75%) than in mothers (5.28 ± 1.49%) and is about equal in brothers (30.71 ± 6.07%) and sisters (35.54 ± 6.28%) of children with IDDM. Among general population the age-corrected lifetime risk for IDDM is equal for males (4.35 ± 0.02%) and females (4.91 ± 0.02%), but is significantly higher for NIDDM in females (27.49 ± 0.04% contrary to 24.07 ± 0.05%).

In comparison with the data of Tillil and Köbberling (1987) our lifetime risk estimates show a shifting of risk for IDDM and NIDDM into older age groups.

Key words

Risk for IDDM - Risk for NIDDM - Diabetes heredity - First-degree relatives of IDDM-persons