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DOI: 10.1055/s-0029-1210841
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Effects of Progesterone and Estradiol on Aminopeptidase A (AAP) and Leucine Aminopeptidase (LAP) Activities in the Pregnancy Serum and Placenta of the Rat
Publikationsverlauf
1988
Publikationsdatum:
16. Juli 2009 (online)
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Summary
We investigated the effects of estradiol and progesterone on placental aminopeptidase A and leucine aminopeptidase activities in pregnant rats. Estradiol (0.5, 1.0 and 2 mg/day) plus progesterone (5, 10 and 20 mg/day) was given for five days starting from the 16th day. Changes in both enzyme activities in the serum, placental cytosol and microsome caused by the steroids were analyzed. Aminopeptidase A activities in all three compartments and leucine aminopeptidase activities in the serum and cytosol were stimulated by estradiol (1.0 mg/day) plus progesterone (10 mg/day). Since we previously found that the placental aminopeptidases degrade peptide hormones, our present study suggests that steroids effect the metabolism of peptide hormones of fetal and/or maternal origin.
Key Words
Aminopeptidase A - Leucine aminopeptidase - Progesterone - Estradiol