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Exp Clin Endocrinol Diabetes 1988; 92(6): 363-365
DOI: 10.1055/s-0029-1210827
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Coincidence of Gonadal Dysgenesis and Hyperprolactinemia

K. Rudolf, S. Kukkel
  • Department of Gynaecology and Obstetrics (Head: OMR Prof. Dr. sc. med. H. WILKEN), Wilhelm-Pieck-University of Rostock, GDR
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Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

It is reported about 4 female patients aged from 3 to 31 years (average age 18 years) with gonadal dysgenesis and hyperprolactinemia. Beside one all these females were not treated with synthetic sexual steroids. In 3 of the 4 patients both hyperprolactinemic and hypergonadotropic serum levels were observed. In one case the gonadotropic serum levels were normal. A stimulation test with GnRH-TRH or arginine-GnRH-TRH, respectively, was performed. In patients with gonadal dysgenesis a change on the area of hypothalamo-hypophyseal axis is supposed to cause the hyperprolactinemia.

Key words

Gonadal dysgenesis - Hyperprolactinemia - Stimulation test - Arginine-GnRH-TRH