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Exp Clin Endocrinol Diabetes 1988; 92(6): 287-296
DOI: 10.1055/s-0029-1210817
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Complement Component 3 (C 3) and Diabetes Mellitus

S. Krantz, F. Stelter, Maria Lober, Ilona Rjasanowski, D. Miohaelis, Barbara Buske
  • Institute of Biochemistry (Director: Prof. Dr. sc. nat. H. Zühlke) of the Ernst Moritz Arndt University Greifswald, Central Institute for Diabetes “Gerhardt Katsch” (Director: Prof. Dr. sc. med. H. Bibergeil) Karlsburg and Diabetes Ambulance of the Medical Centre (Head: Dr. med. B. BUSKE), Greifswald, GDR
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Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

Complement factor 3 (C3) phenotype and allele frequencies were defined in 312 patients with Type 1 diabetes (IDDM), 256 patients with Type 2 diabetes mellitus (NIDDM), 114 apparently healthy first-degree relatives of Type 1 diabetics, in 10 families (29 members) with a familial history of Type 1 or Type 2 diabetes, and 512 controls (blood donors). All persons investigated were Europeans. There is no evidence to suggest that genes linked to C3 influence susceptibility to Type 1 and Type 2 diabetes and to their late complications.

C3 levels in blood plasma were found to be slightly elevated in both types of diabetes. But the C3 concentrations varied considerably within the groups. C3 split products were demonstrable in a high percentage in the blood plasma of freshly manifested Type 1 diabetic persons as well as in Type 1 diabetics with a duration of the disease of 1 to 3 years. C3 proteolysis could also be found in plasma of Type 2 diabetics (26%).

Key words

Complement component 3 (C3) - Genetic polymorphism - Concentration - Degradation - Diabetes mellitus - Type 1 - Type 2