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Exp Clin Endocrinol Diabetes 1988; 92(5): 235-237
DOI: 10.1055/s-0029-1210807
DOI: 10.1055/s-0029-1210807
Original
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
In Vitro Degradation of Opioid Peptides by Human Placental Aminopeptidase M
Further Information
Publication History
1987
Publication Date:
16 July 2009 (online)
![](https://www.thieme-connect.de/media/eced/198805/lookinside/thumbnails/10.1055-s-0029-1210807-1.jpg)
Summary
The degradation of opioid peptides by human placental aminopeptidase M was studied by measuring liberated amino acids by high performance liquid chromatography. The purified placental aminopeptidase M actively degraded Met-enkephalin (Met-Enk) and Leu-enkephalin (Leu-Enk) completely into constituent 5 amino acids. The activities as a function of tyrosine liberation were observed for Met-Enk followed by Leu-Enk, β-neoendorphin, dynorphm, and β-endorphin.
Key words
Placental aminopeptidase M - Degradation of opioid peptides