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Exp Clin Endocrinol Diabetes 1988; 92(5): 235-237
DOI: 10.1055/s-0029-1210807
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

In Vitro Degradation of Opioid Peptides by Human Placental Aminopeptidase M

M. Furuhashi, S. Mizutani, O. Kurauchi, M. Kasugai, O. Narita, Y. Tomoda
  • Department of Obstetrics/Gynaecology, Nagoya University School of Medicine, Nagoya/Japan
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Publication History

1987

Publication Date:
16 July 2009 (online)

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Summary

The degradation of opioid peptides by human placental aminopeptidase M was studied by measuring liberated amino acids by high performance liquid chromatography. The purified placental aminopeptidase M actively degraded Met-enkephalin (Met-Enk) and Leu-enkephalin (Leu-Enk) completely into constituent 5 amino acids. The activities as a function of tyrosine liberation were observed for Met-Enk followed by Leu-Enk, β-neoendorphin, dynorphm, and β-endorphin.

Key words

Placental aminopeptidase M - Degradation of opioid peptides