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Exp Clin Endocrinol Diabetes 1988; 92(5): 177-181
DOI: 10.1055/s-0029-1210798
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Distribution of Subtypes of the BF System in Type 1 (Insulin-Dependent) and Type 2 (Non-Insulin Dependent) Diabetes Mellitus1)

K. P. Ratzmann, G. Geserick, E. Schimke, H. Schröder
  • Center of Diabetes and Metabolic Disorders, Berlin, GDR (Director: MR Dr. sc. med. K. P. Ratzmann) and Institute of Forensic Medicine of the Humboldt University, Berlin, GDR (Director: Prof. Dr. G. Geserick)
1) Presented, in part, at the 21st Annual Scientific Meeting of ESCI, Copenhagen-Elsinor, March 21—24, 1987. The study is part of the Research Project HFR 22 of the Ministry of Health of the G.D.R.
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Publication History

1987

Publication Date:
16 July 2009 (online)

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Summary

In this study 148 type 1 diabetic patients (mean age: 33 years) and 100 type 2 diabetic patients (mean age: 57.3 years) were typed for BF subtypes by means of isoelectrofocusing in polyacrylamide gel (pH range 5.0 — 8.0) according to Geserick. The frequencies of BF subtypes and the distribution patterns were compared with 584 blood donors. In type 1 diabetics the distribution pattern of BF phenotype frequencies differs significantly from the data of type 2 diabetics and controls.

The difference is mainly due to the frequent occurrence of the rare alleles BFF1 and BFSO7. The frequency of the two alleles amounted to 0.0338 and 0.0270, respectively. The relative risk of carriers of the rare alleles BFF1 and BFS07 was 5.3 and 6.6, respectively. The study demonstrates a marked association between the early onset of type 1 diabetes (<20 years of age) and the BFFl allele. There is no relationship between the rare variants of alleles of the BF system and the occurrence of proliferative retinopathy. However, there was no association between the rare variants of alleles of the BF system and type 2 diabetes mellitus. In summary, the study add further support for genetic heterogeneity of the BF system in type 1 diabetes mellitus.

Key words

Diabetes mellitus - Polymorphism - BF system - Genetic heterogeneity