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Exp Clin Endocrinol Diabetes 1988; 92(4): 119-122
DOI: 10.1055/s-0029-1210791
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Insulin Receptors and Glucose Homeostasis in Type 2 Diabetics Influenced by Acetyl-salicylic Acid Treatment

J. Škrha, J. Hilgertová, Š. Svačina, J. Šrámková, J. Páv
  • Department of Internal Medicine 3 (Head: Prof. Dr. V. Pacovský, Dr. Sc), Faculty of Medicine, Charles University, Prague/Czechoslovakia
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Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

The effect of acetyl-salicylic acid administration on insulin receptors on the erythrocytes and the changes of glucose homeostasis examined by hyperglycaemic clamps were evaluated in 8 Type 2 diabetics. Significantly increased number of insulin receptors and decreased insulin affinity constants were found in diabetics after the acetyl-salicylic acid treatment (p < 0.02). Significantly decreased tissue sensitivity to insulin and metabolic clearance rate of insulin (p < 0.02) were observed in Type 2 diabetics after the acetyl-salicylic acid treatment. We conclude that acetyl- salicylic acid may impair glucose homeostasis due to interference with insulin action in peripheral tissues.

Key words

Acetyl-salicyclic acid - Insulin receptors - Hyperglycaemic clamp - Glucose homeostasis