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DOI: 10.1055/s-0029-1210783
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Metastatic Carcinoma to Pituitary Adenomas: A Report of Two Cases
Publikationsverlauf
1987
Publikationsdatum:
16. Juli 2009 (online)
Summary
Two cases of carcinoma metastatic to pituitary adenomas are reported. One patient had a prostatic adenocarcinoma, giving rise to metastases in an adenoma found incidentally at autopsy; clinically and immunohistochemically, the adenoma showed lack of endocrine activity. The second patient had symptoms of cortisol excess. A corticotroph adenoma associated with a malignant neoplasm was diagnosed ante mortem; at autopsy a pancreatic endocrine neoplasm was found. Immunohistochemistry and electron microscopy were important in elucidating the primary tumor.
The formation of extraportal vascular channels and altered blood flow may have importance in the pathogenesis of cancer metastases to pituitary adenomas.
Key words
Electron microscopy - Immunohistochemistry - Metastatic carcinoma - Pituitary adenoma