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Exp Clin Endocrinol Diabetes 1988; 92(4): 20-24
DOI: 10.1055/s-0029-1210776
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

No Diabetogenic Effect of N-Nitrosomethylurea on Pregnant BALB/c Mice and Their Progeny

Christel Voss, H. Zühlke
  • Institute of Biochemistry (Head: Prof. Dr. sc. nat. H. Zühlke), Ernst-Moritz-Arndt-University Medical School, Greifswald/GDR
Further Information

Publication History

1987

Publication Date:
16 July 2009 (online)

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Summary

Our studies give evidence that N-nitrosomethylurea applied to BALB/c mice one day before or after mating or during pregnancy (12th day) even in small (16 or 32 mg/kg) and repeated doses (16 mg/kg on 5 consecutive days, total dose 80 mg/kg) is a more toxic than potent diabetogenic agent. Mortality rises in parent mice and their progeny with no influence on glucose tolerance test and blood glucose level over the whole investigation period (4 hours—12 weeks).

Key words

Diabetes - Nitrosamines - Pregnant mice