Somatostatin Concentrations in Discrete Hypothalamic Nuclei of Genetically Obese Zucker Rats

R. Huupponen; M. Koulu; U.-M. Jaakkola

doi:10.1055/s-0029-1210759

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Exp Clin Endocrinol Diabetes 1988; 91(3): 277-281
DOI: 10.1055/s-0029-1210759

Original

Somatostatin Concentrations in Discrete Hypothalamic Nuclei of Genetically Obese Zucker Rats

R. Huupponen¹ , M. Koulu¹ ^, ² , U.-M. Jaakkola³

¹Department of Pharmacology, University of Turku, Turku, Finland
²Department of Clinical Pharmacology, University of Turku, Turku, Finland
³Central Animal Laboratory, University of Turku, Turku, Finland

Weitere Informationen

Publikationsverlauf

1987

Publikationsdatum:
16. Juli 2009 (online)

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Summary

Hypothalamic somatostatin concentration was determined in 6.5 to 9 months old male and female genetically obese fatty (fa/fa) and lean (Fa/—) Zucker rats. Similar somatostatin levels were found in fatty and lean animals in the hypothalamic regions previously known to contain the highest hormone levels (median eminence and arcuate, periventicular and ventromedial nuclei). The fatty animals were grossly obese and had a pronounced hyperinsulinemia.

Key words

Somatostatin - Zucker rat

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