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DOI: 10.1055/s-0029-1210748
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Coexistence of Somatostatin-immunoreactivity in an Adrenal Pheochromocytoma and a Thyroid Medullary Carcinoma (Sipple syndrome)
Publikationsverlauf
1987
Publikationsdatum:
16. Juli 2009 (online)
Summary
The presence of somatostatin-immunoreactivity in tumor tissue of adrenal pheochromocytoma and thyroid medullary carcinoma identified by peroxidase-antiperoxidase technique is reported in one case of Sipple syndrome. This patient was found to have a high concentration of somatostatin-immunoreactivity in the peripheral blood (40 ng/l, normal 0-20 ng/l). After removal of the tumors, the plasma somatostatin-immunoreactivity fell within normal range (12.5 ng/l).
This seems to be the first report of Sipple syndrome that produces somatostatin-immunoreactivity in both: pheochromocytoma and thyroid medullary carcinoma.
Key words
Sipple syndrome - Somatostatin - Pheochromocytoma - Thyroid medullary carcinoma