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Exp Clin Endocrinol Diabetes 1987; 90(5): 213-220
DOI: 10.1055/s-0029-1210692
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Hyponatremia and Increased Secretion of Vasopressin Induced by Vincristine Administration in Rat

I. Jójárt, F. Laczi, F. A. László, Krisztina Boda, S. Csáti, T. Janáky
  • Endocrine Unit and Research Laboratory (Head: Prof. F. A. László), First Department of Medicine (Head: Prof. V. Varró), and Computing Centre (Head: Assoc. Prof. I. Győri) University Medical School, Szeged/Hungary
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Publication History

1987

Publication Date:
16 July 2009 (online)

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Summary

Administration of vincristine resulted in a hyponatremic state and concurrent elevation of the plasma immunoreactive arginine8-vasopressin (IR-AVP) level in rats. Development of the vincristine-induced hyponatremia and hypoosmolality was accompanied by a loss in weight, a decreased water intake and a large reduction in the daily urine sodium excretion. The cause of the sodium loss is thought to be the diarrhea observed during vincristine treatment. Hematocrit and serum urea nitrogen levels were increased.

It is concluded that the condition differs from the syndrome of inaproppriate secretion of anti-diuretic hormone (SIADH) : the increase in plasma IR-AVP concentration may be associated with dehydration due to vincristine toxicity.

Key words

Vincristine toxicity - Hyponatremia - Vasopressin - Dehydration