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Exp Clin Endocrinol Diabetes 1987; 89(3): 297-300
DOI: 10.1055/s-0029-1210653
DOI: 10.1055/s-0029-1210653
Original
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Insulin-Dependent Diabetes: Strategy for Immune Intervention
Further Information
Publication History
1986
Publication Date:
16 July 2009 (online)
Summary
Increasingly, experimental results are underlining the role played by autoimmune mechanisms in the pathogenesis of type I insulin-dependent diabetes mellitus (IDDM). It has appeared logical to attempt to preclude the onset of IDDM by suppressing immune responses, but trials using steroids or azathioprine were unequivocal. Subsequently, a Canadian and a French group performed pilot studies to assay a new immunosuppressive drug, cyclosporine A (CyA) in human diabetes (Stiller et al., 1984; Assan et al., 1985). However, further testing is required to evaluate and confirm its potential benefits and possible risks.
Key words
Diabetes - Immunosuppression - Cyclosporine A