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Exp Clin Endocrinol Diabetes 1987; 89(1): 105-108
DOI: 10.1055/s-0029-1210634
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Influence of Microinjection of Glucagon into Ventromedial Hypothalamus on Acetate Metabolism in Liver Slices of Rabbit

K. Seto, H. Saito, H. Kaba, J. Tanaka, Y. Takeshima, N. Edashige1 , K. Kitaoka, M. Kawakami2
  • 1First Department of Physiology (Chairman: Prof. Dr. K. Seto), Kochi Medical School, Nankoku, Department of Medical Technology (Chairman: Prof. Dr. S. Sato), Yokohama City University School of Medicine, Yokohama/Japan
  • 2Kochi Gakuen College, Kochi, Second Department of Physiology (Former Chairman: Prof. Dr. M. Kawakami), Yokohama City University School of Medicine, Yokohama/Japan
Further Information

Publication History

1986

Publication Date:
16 July 2009 (online)

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Summary

Glucagon was injected directly into the ventromedial hypothalamic nuclei (VMH) of rabbits, and changes in hepatic acetate metabolism were studied. The injection of 3ng glucagon into the VMH of intact rabbits increased the rates of 14C transfer from 14C-l-acetate into CO2, glucose and ketone bodies but decreased those into cholesterol ester, triglyceride, free cholesterol, free fatty acids and phospholipids. However, after glucagon injection into the VMH of rabbits with VMH lesions and the parietal cortex of intact rabbits, hepatic acetate metabolism did not differ from that of the control rabbits, which received saline injection into the same brain regions. These observations support the hypothesis that the VMH are parts of a glucagon-sensitive brain regulator system in the hepatic acetate metabolism.

Key words

Glucagon-acetate metabolism - Ventromedial hypothalamus - Rabbit's liver