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Exp Clin Endocrinol Diabetes 1986; 88(5): 185-192
DOI: 10.1055/s-0029-1210595
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Molecular Interaction of Nonsteroidal Compounds with Uterine Progesterone Receptor (Part I)1)

Anila Agnihotri,  Neelima, Shri Niwas, B. K. Bhat, Shiv Kumar, M. Seth, A. P. Bhaduri, A. K. Srivastava, V. P. Kamboj
  • Division of Endocrinology (Head: Dr. V. P. Kamboj), Central Drug Research Institute, Lucknow/India
1) CDRI Communication No. 3603.
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Publication History

1986

Publication Date:
16 July 2009 (online)

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Summary

Progesterone-receptor binding affinity of some nonsteroidal molecules was assessed by competitive protein binding assay in rabbit as well as human uterine cytosol in vitro. Of 40 compounds belonging to 5 different series tested, 3-(p-anisoyl)-2-chloro-6, 7-dimethoxy-quinoline exhibited around 50% inhibition whereas 2-(p-anisoyl) naphthalene and 3-substituted phenyl-l-(3-(2-chloro-6,7-dialkoxy) quinolinyl)prop-2-en-l-one showed around 20% inhibition in 3H-progesterone binding for rabbit and human uterine progesterone receptor.

Key words

Rabbit - Human - Progesterone - Receptor - Inhibition