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Exp Clin Endocrinol Diabetes 1986; 88(5): 158-164
DOI: 10.1055/s-0029-1210591
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Short- and Long-term Effects of Angiotensin II on the Rat Adrenal Zona Glomerulosa

A Coupled Stereological and Enzymological StudyG. G. Nussdorfer, A. Kasprzak1 , G. Mazzocchi, P. Rebuffat, L. K. Malendowicz1 , C. Robba
  • Department of Anatomy, University of Padua/Italy
  • 1Department of Histology and Embryology, Academy of Medicine, Poznań/Poland
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Publication History

1985

Publication Date:
16 July 2009 (online)

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Summary

Long-term angiotensin II administration induced a time-dependent increase in the volume of rat zona glomerulosa cells and in the plasma concentration of aldosterone. Cell hypertrophy is coupled with comparable increases in the surface area per cell of mitochondrial cristae and in the activity per cell of 18-hydroxylase. 11β-hydroxylase activity was not affected. These findings allow to suggest that the angiotensin-II-enhanced growth of rat zona glomerulosa is associated with the de novo synthesis of 18-hydroxylase.

Key words

Adrenal cortex - Zona glomerulosa - Renin-angiotensin system - Steroidogenesis - Morphometry