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Exp Clin Endocrinol Diabetes 1986; 88(4): 76-80
DOI: 10.1055/s-0029-1210578
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Insulin Binding to Erythrocyte Receptors in Acromegalic Patients in Relation to the Activity of Acromegaly and to Concomitant Diabetes Mellitus

J. Páv, Jiřina Hilgertová, J. Marek, Jarmila Šrámková
  • 3rd Medical Clinic (Head: Prof. Dr. med. V. Pacovsky, DrSc), Faculty of General Medicine, Charles University, Prague/Czechoslovakia
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Publication History

1985

Publication Date:
16 July 2009 (online)

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Summary

Insulin binding to receptors on erythrocytes was studied in patients with acromegaly (n = 27) and in control subjects without any endocrine pathology, diabetes or obesity (n= 13). According to fasting serum concentration of growth hormone (GH), acromegalics were divided into two groups: A) GH less than 10ng/ml (n = 16) and B) GH above 20ng/ml (n = 11), in which patients were further divided into subgroups with regard to the presence or absence of diabetes. Insulin binding was decreased both in active and inactive acromegalics when compared with controls. A greater decrease was seen in active acromegaly coupled with diabetes. This was not the case of inactive hyperglycaemic acromegalics, where a compensatory increase in the affinity of “empty” receptors might account for a lack of a greater decrease in insulin binding.

Key words

Insulin receptors - Acromegaly - Diabetes mellitus - Erythrocytes

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