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DOI: 10.1055/s-0029-1210570
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Reproductive Functions in the Adult Male Rats after Prolonged Intraventricular Administration of Corticotropin-Releasing Factor (CRF)
Publication History
1985
Publication Date:
16 July 2009 (online)
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Summary
The effect of intraventricular injection of synthetic oCRF on reproductive functions in the male rats were studied and changes were compared with intact and control rats (daily intra -ventricular injections of 10 μl of 0.1% albumin solution in PBS). The long-term administration of oCRF into lateral ventricle of freely moving rats caused a significant increase in relative weights of adrenals, pituitary glands and a decrease in body weight. Plasma LH and testosterone levels were significantly depressed after 8 days of oCRF administration, while there were no alteration in studied parameters in the control rats. Control i.v.c. injections of 0.1% albumin solution in PBS were without effect on levels of any of the hormones or weights of testes, epidydimis, seminal vesicles and prostate. Obtained results indicate a central inhibitory action of oCRF on LH and subsequent testosterone release.
Key words
CRF - LH - Testosterone - Reproductive system