Download PDF
Exp Clin Endocrinol Diabetes 1986; 87(3): 333-336
DOI: 10.1055/s-0029-1210563
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Specific Immunotherapy in Insulin-Dependent Diabetes Mellitus (Preliminary Report)

D. Lohmann, B. Bierwolf, J. Krug, E. Lampeter, H.-J. Verlohren
  • City Hospital (Head: Prof. Dr. D. Lohmann) Leipzig/GDR
Further Information

Publication History

1986

Publication Date:
16 July 2009 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

In 7 patients with newly diagnosed insulin-dependent diabetes mellitus a cytotoxic effect of blood lymphocytes against B-cells could be demonstrated by incubation of isolated rat islets with the lymphocytes. The addition of lymphocytes from healthy persons significantly Yeduced this effect in vitro. The transfusion of 1.9 ×109 — 1.5 ×1010 lymphocytes from the parents to the patients produced a significant decrease of the cytotoxic effect of the lymphocytes from the patients. This effect could be demonstrated during the preliminary control period up to 12 weeks.

Key words

Inhibition of cytotoxic effects - Insulin-dependent diabetes mellitus - Lymphocyte transfusion - Suppressor cell defect

      >