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Exp Clin Endocrinol Diabetes 1986; 87(2): 157-161
DOI: 10.1055/s-0029-1210537
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Chronic Angiotensin Treatment Stimulates the Growth and the 11β-Hydroxylase Activity of Rat Zona Fasciculata Cells

G. Mazzocchi, G. G. Nussdorfer
  • Department of Anatomy, University of Padua/Italy
Further Information

Publication History

1985

Publication Date:
16 July 2009 (online)

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Summary

Long-term angiotensin-II (All) administration provokes a time-dependent rise in the volume of zona fasciculata cells and in the plasma concentration of corticosterone in rats treated with dexamethasone and maintenance doses of ACTH. The AII-induced zona fasciculata cell hypertrophy is coupled with comparable increases in the surface area per cell of the mitochondrial cristae and in the activity per cell of llβ-hydroxylase. These findings suggest that All enhances the growth and the steroidogenic capacity of rat adrenal zona fasciculata.

Key words

Adrenal cortex - Renin-angiotensin system - Steroidogenesis - Morphometry

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