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Exp Clin Endocrinol Diabetes 1986; 87(1): 31-37
DOI: 10.1055/s-0029-1210519
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

ACTH Secretory Responsiveness of Pituitary Adrenotroph Cell Tumor to Adrenocorticotropin-Releasing Factor in Cushing's Disease and Nelson's Syndrome

R. Takeda, T. Ito, M. Kawato, H. Nakabayashi, I. Miyamori, T. Morise, H. Koshida, M. Ikeda
  • Second Department of Medicine (Head: Prof. Dr. R. Takeda),
    School of Medicine, Kanazawa University (Head: Prof. Dr. S. Nishida), Kanazawa/Japan
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Publication History

1984

Publication Date:
16 July 2009 (online)

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Summary

ACTH-secretory responsiveness of the adrenotroph cell tumors to the exogenous CRF was evaluated in 4 cases of Cushing's disease and 3 cases of Nelson's syndrome.

Significantly exaggerated ACTH release was evoked by the intravenous injection of CRF in all 3 cases of Nelson's syndrome, but in Cushing's disease there seemed to be an individual difference in the sensitivity of the pituitary to CRF, probably depending on the functional activity of hypothalamo-pituitary axis.

Key words

Cushing's disease - Nelson's syndrome - CRF