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Exp Clin Endocrinol Diabetes 1985; 86(6): 266-272
DOI: 10.1055/s-0029-1210496
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Carbohydrate Metabolism in the Genital Organs of Adult Female Rhesus Monkeys: Effect of Prolonged Treatment with Centchroman, an Antiimplantation Agent

Vinita Wadhwa, M. M. Singh, V. P. Kamboj
  • Division of Endocrinology (Head: Dr. V. P. Kamboj), Central Drug Research Institute (Director: Dr. Nitya Anand), Lucknow/India
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Publikationsverlauf

1984

Publikationsdatum:
16. Juli 2009 (online)

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Summary

Weekly oral administration of centchroman at 1 and 2.5 mg/kg doses for 3, 6 or 12 months to adult female rhesus monkeys (Macaco, mulatto) significantly decreased glycogen content and activity of phosphorylase, glucokinase, lactate dehydrogenase and glucose 6-phosphate dehydro-genase enzymes in all the genital tract tissues. In general, the inhibition was dose and time dependent. No effect was, however, observed in the liver and serum.

Key Words

Centchroman - Macaque - Enzymes - Genital tract