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DOI: 10.1055/s-0029-1210422
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Further Support for Inhibition of Endogenous Insulin Secretion by Exogenous Insulin*
* Dedicated to Professor H. Bibergeil on the Occassion of his 60th Birthday.Publication History
1984
Publication Date:
16 July 2009 (online)
Summary
In order to investigate whether or not insulin exerts any influence on endogenous insulin secretion, 6 non-obese healthy volunteers were connected to the artificial beta-cell (BIOSTATOR) for 16 hours.
After an overnight fast 0.4 U of intermediate acting insulin (Monotard MC/NOVO INDUSTRIES) per kg body weight were injected subcutaneously. The computer program was set to maintain steady-state plasma glucose concentrations at fasting levels by a variable glucose infusion. This approach is able to prevent completely hypoglycemic episodes.
Endogenous insulin secretion was evaluated by measuring plasma C-peptide concentrations.
Whereas plasma insulin levels increased markedly in response to insulin injection at the same time C-peptide levels declined correspondingly, indicating an inhibition of insulin secretion.
Thus, our results provided further support for a negative feedback regulation of insulin secretion by insulin itself.
Key words
Insulin - Feedback inhibition - Beta cell function