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Exp Clin Endocrinol Diabetes 1985; 85(1): 75-80
DOI: 10.1055/s-0029-1210422
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Further Support for Inhibition of Endogenous Insulin Secretion by Exogenous Insulin*

K.-P. Ratzmann, B. Schulz
  • Central Institute of Diabetes “Gerhardt Katsch” (Director: OMR Prof. Dr. sc. med. H. Bibergeil), I. Clinical Department (Director: OMR Prof. Dr. sc. med. B. Schulz), Karlsburg/GDR
* Dedicated to Professor H. Bibergeil on the Occassion of his 60th Birthday.
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Publication History

1984

Publication Date:
16 July 2009 (online)

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Summary

In order to investigate whether or not insulin exerts any influence on endogenous insulin secretion, 6 non-obese healthy volunteers were connected to the artificial beta-cell (BIOSTATOR) for 16 hours.

After an overnight fast 0.4 U of intermediate acting insulin (Monotard MC/NOVO INDUSTRIES) per kg body weight were injected subcutaneously. The computer program was set to maintain steady-state plasma glucose concentrations at fasting levels by a variable glucose infusion. This approach is able to prevent completely hypoglycemic episodes.

Endogenous insulin secretion was evaluated by measuring plasma C-peptide concentrations.

Whereas plasma insulin levels increased markedly in response to insulin injection at the same time C-peptide levels declined correspondingly, indicating an inhibition of insulin secretion.

Thus, our results provided further support for a negative feedback regulation of insulin secretion by insulin itself.

Key words

Insulin - Feedback inhibition - Beta cell function