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Exp Clin Endocrinol Diabetes 1984; 84(6): 352-355
DOI: 10.1055/s-0029-1210410
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Teratomorphogenic Effects on the Brain Produced by Neonatal Maternal Deprivation Can Be Partly Prevented by Pyridostigmine Administration

G. Dörner, M. Plaschke1 , R. Tönjes, J. Wenzel1
  • Institute of Experimental Endocrinology (Head: Prof. Dr. sc. med. G. Dörner)
  • 1Institute of Anatomy (Head: Prof. Dr. sc. med. R. Bertolini), Humboldt University Medical School (Charité), Berlin/GDR
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1984

Publikationsdatum:
17. Juli 2009 (online)

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Summary

Maternal deprivation from the 3rd to 14th day of life, i.e., separation of the pups from their mother animals for 16 hours each day, gave rise to persistent significant changes of micro-structures in the hippocampal stratum radiatum of the CA1-region, which were associated with significantly decreased emotionality, learning capability and memory capacity in adulthood. Such teratomorphogenic effects on the brain produced by psychosocial and/or nutritional deprivation during brain development could be partly prevented — as well as the teratophysiogenic and tera-topsychogenic effects— by simultaneous administration of the acetylcholinesterase inhibitor pyridostigmine.

Key words

Teratomorphogenesis of the brain - neonatal maternal deprivation - neurotransmitters - pyridostigmine

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