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Exp Clin Endocrinol Diabetes 1984; 83(3): 269-274
DOI: 10.1055/s-0029-1210340
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Studies on the Inhibitory Effect of Apomorphine and Bromocryptine on Basal and TRH Induced Level of TSH and PRL in Hypothyroid Rats under Pentobarbiturate Anesthesia

P. Langer, B. Mess1 , O. Földes, CS. Ruzsás1 , H. Brozmanová, K. Straussová, K. Gschwendtová
  • Institute of Experimental Endocrinology, Center of Physiological Sciences SAV, Bratislava/Czechoslovakia
  • 1Department of Anatomy, University Medical School, Pécs/Hungary
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Publikationsverlauf

1982

Publikationsdatum:
17. Juli 2009 (online)

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Summary

Groups of male rats were inserted with polyethylene tubings into femoral artery and vein under pentobarbiturate anesthesia and small blood samples were frequently taken for the estimation of TSH and PRL under maintaining isovolemia. After a single injection of apomorphine (12 mg kg−1) or bromocryptine (20 mg kg−1) much more expressed effect of these drugs on a decrease of PRL level in plasma was found than that on a decrease of TSH level and similar observation was made with the use of continuous i. v. infusion of apomorphine (50 μg in 20 μl per min for 180 min). Finally, under the above dose of infused apomorphine, the effect of TRH on the increase of TSH level was depressed at the 30th min as compared to that 0 and 120th min of infusion. In addition, at 120 min of infusion the effect of TRH was significantly higher than that at 0 min. These results suggest that the effect of apomorphine may take place at the pituitary level.

Key words

Apomorphine - bromocryptine - TSH - PRL - hypothyroid rats

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