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Exp Clin Endocrinol Diabetes 1983; 81(3): 315-320
DOI: 10.1055/s-0029-1210242
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Clonidine (Haemiton®) as a Reliable Stimulus of Growth Hormone Secretion in Patients with Short Stature

E. Keller, Dietlinde Sorger, H. Willgerodt
  • Department of Paediatrics (MR Prof. Dr. sc. med. W. Braun) and Department of Nuclear Medicine (OMR Prof. Dr. sc. med. W. Oelßner) Karl-Marx-University, Medical School, Leipzig/GDR
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Publication History

1982

Publication Date:
17 July 2009 (online)

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Summary

In 14 patients with short stature aged 4–14 years the effect of clonidine has been investigated. A single oral dose of 0.15 mg/m2 surface area is followed by a marked increase of hGH concentration in blood with a peak value between 60 and 90 min after the administration of the drug. The hGH increase caused by clonidine was comparable to the rise during insulin-induced hypoglycemia. In 5 patients both stimuli failed to increase hGH release. The test procedure is simple. It shows only minimum side effects and can therefore be especially recommended in outpatients.