Experimental Hypo/Hyperthyroidism in Rats and the Perinatal Development of the Hypothalamo-Neurohypophysial System in Comparison with the Thyroid Gland State and External Features

Renate Kiessig; G. Wolf; K. Dietzmann

doi:10.1055/s-0029-1210240

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Exp Clin Endocrinol Diabetes 1983; 81(3): 297-307
DOI: 10.1055/s-0029-1210240

Original

Experimental Hypo/Hyperthyroidism in Rats and the Perinatal Development of the Hypothalamo-Neurohypophysial System in Comparison with the Thyroid Gland State and External Features

Renate Kiessig, G. Wolf, K. Dietzmann

Department of Biology (Head : Prof. G. Wolf) of the Institute of Anatomy and Biology (Director: Prof. Dr. A. Dorn) and Institute of Pathology (Director: Prof. Dr. W. Kühne) Medical Academy of Magdeburg/GDR

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Publication History

1982

Publication Date:
17 July 2009 (online)

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Summary

Neurophysin was detected immunohistochemically in the hypothalamo-neurohypophysial system of Wistar rats not before fetal day 18. Formerly, neurophysin was identified on day 16 of intrauterine life using another breeding stock of Wistar rats, but the same immunohistochemical reagents. In pregnant rats, experimentally induced hypo/hyperthyroidism beginning with day 13 of gestation failed to show any evident influence on the first appearance of immunohistochemically detectable neurophysin during the fetal development. Otherwise, significant effects on fetal body growth and other external features as well as the fetal thyroid state and histochemically demonstrable thyroid peroxidase activity were shown. The influence of thiamazol on the fetal thyroid peroxidase points out a primary effect and indicates the permeability of the placenta to this anti-thyroid drug.