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Exp Clin Endocrinol Diabetes 1983; 81(3): 273-279
DOI: 10.1055/s-0029-1210236
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Diurnal Variation in Specific Insulin Binding to Erythrocytes

B. Schulz, M. Greenfield, G. M. Reaven
  • Clinical Research Center (Director: G. M. Reaven, M.D.), Stanford University School of Medicine, Stanford [California]/U.S.A. and Central Institute of Diabetes „Gerhardt Katsch“ (Director: OMR Prof. Dr. sc. med. H. Bibergeil), Karlsburg/GDR
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Publication History

1982

Publication Date:
17 July 2009 (online)

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Summary

We studied the insulin binding to erythrocytes during a 24-h period in 11 normal subjects.

Compared with 0800 and 1600 h the specific 125I-insulin binding decreased significantly at mid-night. These changes were mainly due to alterations in insulin binding affinity rather than a decrease in receptor number.

An inverse finding was obtained concerning the plasma insulin levels. In fact, the highest insulin concentrations were observed at midnight.

The results suggest that diurnal variations in insulin receptor function occur in response to fluctuations of plasma insulin levels.