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Exp Clin Endocrinol Diabetes 1983; 81(2): 115-121
DOI: 10.1055/s-0029-1210217
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Progestagenic and Antigonadotrophic Activities of STS 5571)

W. Stölzner, A. Kurischko, H. Freund, R. Freund, M. Méyer, M. Oettel
  • Academy of Sciences of the GDR, Research Centre of Molecular Biology and Medicine; Central Institute of Microbiology and Experimental Therapy (Director: Prof. Dr. U. Taubeneck), Jena/GDR
1) This work was supported in part by a grant from the World Health Organization.
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1982

Publikationsdatum:
17. Juli 2009 (online)

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Summary

STS 557 (17α-cyanomethyl-17β-hydroxy-estra-4, 9-dien-3-one) was tested for progestagenic activity in rabbits and for ovulation-inhibiting activities in rabbits and rats in comparison with levonorgestrel and, in some cases, with norethisterone acetate or chlormadinone acetate.

In the immature rabbit, the endometrium transformation-inducing activity of STS 557 was about 5 times higher than levonorgestrel for both oral and subcutaneous administration.

The ovulation-inhibiting effect of STS 557 was 3.5 times higher than that of levonorgestrel in the rabbit after oral administration, and about 7 times higher in the rat. After subcutaneous injection, however, the antiovulatory activity of STS 557 in rats was only about 4% of that of levonorgestrel when the ED 50 were compared.