Planta Med 2010; 76(5): 458-460
DOI: 10.1055/s-0029-1186226
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Two New Peltogynoids from Acacia nilotica Delile with Kinase Inhibitory Activity

Augustine Ahmadu1 , 2 , Agunu Abdulkarim3 , Raphaël Grougnet1 , 4 , Vassilios Myrianthopoulos1 , François Tillequin4 , Prokopios Magiatis1 , Alexios-Leandros Skaltsounis1
  • 1Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens, Greece
  • 2Department of Pharmaceutical Chemistry, Niger-Delta University, Wilberforce Island, Yeanagoa, Nigeria
  • 3Department of Pharmacognosy and Drug development, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria
  • 4Laboratoire de Pharmacognosie de l'Université René Descartes, UMR/CNRS 8638, Faculté de Pharmacie, Paris, France
Further Information

Publication History

received July 9, 2009 revised September 13, 2009

accepted September 22, 2009

Publication Date:
20 October 2009 (online)

Abstract

Two new peltogynoids, acanilol A (1) and acanilol B (2), were isolated from the stem bark of Acacia nilotica (L.) Delile, together with the known triterpene lupenone. The structures of the new compounds were established on the basis of their spectral data, mainly UV, NMR, and mass spectrometry. The new compounds were tested as kinase inhibitors against CDK1, GSK3, CK1, and DYRK1A, and acanilol B was identified as a DYRK1A inhibitor, with an IC50 of 19 µM.

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Prof. Dr. Prokopios Magiatis

Department of Pharmacognosy and Natural Products Chemistry
Faculty of Pharmacy
University of Athens

Panepistimiopolis-Zografou

15771 Athens

Greece

Phone: + 30 21 07 27 40 52

Fax: + 30 21 07 27 45 94

Email: magiatis@pharm.uoa.gr