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DOI: 10.1055/s-0029-1186035
© Georg Thieme Verlag KG Stuttgart · New York
Ganoderic Acids from Ganoderma lucidum: Inhibitory Activity of Osteoclastic Differentiation and Structural Criteria
Publikationsverlauf
received March 15, 2009
revised July 10, 2009
accepted July 14, 2009
Publikationsdatum:
10. August 2009 (online)
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Abstract
Increased osteoclastic bone resorption plays a central role in the pathogenesis of many bone diseases. Ganoderma lucidum is known for medicinal effects such as anti-inflammatory and anti-bone resorption activities. In this study, we investigated the inhibitory effects of ganoderic acids isolated from G. lucidum on osteoclastic differentiation using RAW264 cells in vitro. A carbonyl in C7 is essential to elicit the inhibition of osteoclast differentiation.
Key words
Ganoderma lucidum - Ganodermataceae - triterpenoids - ganoderic acids - osteoclastic differentiation
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Prof. Ryuichiro Kondo
Department of Forest and Forest Products Sciences
Faculty of Agriculture
Kyushu University
6-10-1 Hakazaki, Higashiku
812–8581 Fukuoka
Japan
Telefon: + 81 9 26 42 28 11
Fax: + 81 9 26 42 28 11
eMail: ryukondo@agr.kyushu-u.ac.jp
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