Abstract
Three new benzamide derivatives, N-{[p-(3,7-dimethyl-6R,7-dihydroxy-4R-octadecanoyloxy-2-octenyloxy)phenyl]ethyl} benzamide (1), N-{[p-(3,7-dimethyl-6R,7-dihydroxy-4R-9′′′(E)-octadecenoyloxy-2-octenyloxy)phenyl]ethyl} benzamide (2), and N-{[p-(3,7-dimethyl-6R,7-epoxy-4R-9′′′(E)-octadecenoyloxy-2-octenyloxy)phenyl]ethyl} benzamide (3), together with 10 known compounds (4–13), were isolated from the bark of Limonia acidissima. The structures of these new compounds were determined through spectral analyses, including extensive 2D NMR data. Among the isolates, 13α,14β,17α-lanosta-7,9,24-triene-3β,16α-diol (8), 4-methoxy-1-methyl-2(1H)-quinolinone (10), and 13α,14β,17α-lanosta-7,24-diene-3β,11β,16α-triol (13) potently inhibited nitric oxide (NO) production in microglia cells.
Key words
Limonia acidissima
- Rutaceae - benzamide derivative - NO production inhibitory activity
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Prof. Dr. Kang Ro Lee
Natural Products Laboratory
College of Pharmacy
Sungkyunkwan University
300 Chonchon-dong
Jangan-ku, Suwon 440–746
Korea
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