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DOI: 10.1055/s-0029-1185512
© Georg Thieme Verlag KG Stuttgart · New York
New Benzamide Derivatives and NO Production Inhibitory Compounds from Limonia acidissima
Publication History
received July 9, 2008
revised January 12, 2009
accepted February 17, 2009
Publication Date:
02 April 2009 (online)
![](https://www.thieme-connect.de/media/plantamedica/200910/lookinside/thumbnails/10.1055-s-0029-1185512-1.jpg)
Abstract
Three new benzamide derivatives, N-{[p-(3,7-dimethyl-6R,7-dihydroxy-4R-octadecanoyloxy-2-octenyloxy)phenyl]ethyl} benzamide (1), N-{[p-(3,7-dimethyl-6R,7-dihydroxy-4R-9′′′(E)-octadecenoyloxy-2-octenyloxy)phenyl]ethyl} benzamide (2), and N-{[p-(3,7-dimethyl-6R,7-epoxy-4R-9′′′(E)-octadecenoyloxy-2-octenyloxy)phenyl]ethyl} benzamide (3), together with 10 known compounds (4–13), were isolated from the bark of Limonia acidissima. The structures of these new compounds were determined through spectral analyses, including extensive 2D NMR data. Among the isolates, 13α,14β,17α-lanosta-7,9,24-triene-3β,16α-diol (8), 4-methoxy-1-methyl-2(1H)-quinolinone (10), and 13α,14β,17α-lanosta-7,24-diene-3β,11β,16α-triol (13) potently inhibited nitric oxide (NO) production in microglia cells.
Key words
Limonia acidissima - Rutaceae - benzamide derivative - NO production inhibitory activity
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Prof. Dr. Kang Ro Lee
Natural Products Laboratory
College of Pharmacy
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