Planta Med 2009; 75(4): 337-339
DOI: 10.1055/s-0028-1112208
Pharmacology
Letter
© Georg Thieme Verlag KG Stuttgart · New York

In vitro Anti-Influenza Viral Activities of Constituents from Caesalpinia sappan

Ai-Lin Liu1 , Shi-Hui Shu1 , Hai-Lin Qin1 , Simon Ming Yuen Lee2 , Yi-Tao Wang2 , Guan-Hua Du1
  • 1Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China
  • 2Institute of Chinese Medical Sciences, University of Macau, Macao, P. R. China
Further Information

Publication History

Received: July 1, 2008 Revised: October 28, 2008

Accepted: November 4, 2008

Publication Date:
15 January 2009 (online)

Abstract

Six constituents with neuraminidase (NA) inhibitory activity, namely brazilein, brazilin, protosappanin A, 3-deoxysappanchalcone, sappanchalcone and rhamnetin, were isolated from the hearthwood of Caesalpinia sappan (Leguminosae). Their in vitro anti-influenza virus activities were evaluated with the cytopathic effect (CPE) reduction method. The results showed that 3-deoxysappanchalcone and sappanchalcone exhibited the highest activity against influenza virus (H3N2) with IC50 values of 1.06 and 2.06 μg/mL, respectively, in comparison to the positive control oseltamivir acid and ribavirin with IC50 values of 0.065 and 9.17 μg/mL, respectively.

Abbreviations

CPE:cytopathic effect

NA:neuraminidase

References

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Dr. Simon Ming Yuen Lee

Institute of Chinese Medical Sciences

University of Macau

Taipa

Macao

People′s Republic of China

Phone: +853-8397-4695

Fax: +853-8441-358

Email: simonlee@umac.mo

Prof. Dr. Guan-Hua Du

Institute of Materia Medica

Chinese Academy of Medical Sciences and Peking Union Medical College

Beijing 100050

People′s Republic of China

Phone: +86-10-6316-5184

Fax: +86-10-6301-7757

Email: dugh@imm.ac.cn